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In this review, we discuss how peptide-based tumor immunotherapy transforms PCa from a cold to a hot state by modulating the TME of PCa and inducing ICD in PCa cells, thereby enhancing the response of PCa to immunotherapy

For individuals with a single wound focus, local injection provides the most direct delivery

8.1.4 Research limitations and considerations While the evidence is compelling, several limitations must be acknowledged, including the reliance on observational studies for human data, potential confounding factors in epidemiological investigations, and the extrapolation challenges from animal models to human populations

However, safety depends on several factors: The specific peptide and dose The dogs age, breed, and health status The quality and purity of the peptide product The duration of use Some dogs may experience mild injection site irritation or digestive upset

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